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Friday, May 28, 2021

Watson, Crick, Franklin, Wilkins & Scientific Wisdom.

DNA Pioneers: James Watson, Francis Crick, Maurice Wilkins and Rosalind Franklin. 


I recently re-watched a video I had recorded way back in the March of 2003. It was recorded from the UK's Channel 4 and was entitled DNA: The secret of life. It told the story of the discovery of the structure of DNA. James Watson, Francis Crick and Maurice Wilkins appeared on the programme. Also appearing was Raymond Gosling who at the time was a PhD student and lab assistant to Rosalind Franklin. According to the program Franklin and Wilkins of King's College were the experimentalists who generated the X-Ray diffraction patterns which so helped Crick and Watson to successfully theorise about the structure of DNA. It's not that the King's College team weren't theorists themselves, but they also did the hard work of getting the necessary experimental data about DNA. It is very easy to put Crick and Watson into the role of the "lazy lads" who just theorised together down at the pub and let others do the hands-on science. That they appeared to be riding on the backs of others was the cause of tension. But whatever, they were clearly very bright guys who can rightly claim credit for making the right inferences from the data. It didn't help the King's College team that Franklin and Wilkins had a poor relationship; in contrast it seems that Watson and Crick worked well together (and drank well together!). Also, that Franklin was a pretty woman in a largely man's world may have introduced frustrating pressures and detrimentally affected her attitudes. Or perhaps she was just a awkward personality.

The programme tells us of Watson and Crick's first attempt at a model. The King's College team came to have a look at this model. But when Rosalind Franklin saw it she laughed out loud; in the light of the experimental data the King's team had accumulated the model was clearly wrong. Watson & Crick were suffering from their working in a too rarified experimental semi-vacuum. Then one day Wilkins, who seems to have been an obliging sort of character, showed Watson an X shaped diffraction pattern that the King's team had obtained. Watson and Crick knew immediately that this implied DNA was a double helix and they went on to develop the correct model we are all familiar with.  Lab assistant Ray Gosling takes up the story:

Wilkins undoubtedly (and I think if you ask him he will say he did), if there are any cats to be let out of any bags, he had done it.

To which Wilkins responded:

Well I suppose it's perfectly true, but science isn't supposed to be kept in bags, no more than cats. I mean, I don't know what he means but I don't like as a scientist working away and sort of "Oh no! I mustn't tell the other scientists". I don't think it's the way to be working. Science ought to be an open activity, so you can work as a community. 

Well yes, in theory, that's the ideal world: that's wisdom we should aspire to, take home and act on: But no, we aren't in that kind of world; we're in a human world. Human beings can't be so detached and dispassionate. Competition, reputations, making a name for yourself, not to mention wealth & fame are at stake and have a strong tendency to trump the cooperation and community effort thing. The consequent mutual distrust means that people keep their cards close to their chests. Competition vs community effort! It's all very reminiscent of the capitalist conundrum of free market vs community.  And yet again I'm reminded of Philippians 2:1-11 which seems to be the key to community living

During the program, Maurice Wilkins also came out with another pearl of Wisdom. As we've seen Crick and Watson's first model was laughed off stage by Rosalind Franklin. But of this failed attempt Wilkins comments wisely as follows:

One might say but why not? It's an exploration to make a model. You make a model and if you make a bit of a fool of yourself in the process why worry? ....you might get lucky!

A big lesson there for all blue sky theorists: Its any exploration and there's no telling whether you are going to  make a fool of yourself or win the jackpot - most likely the former,. So enjoy he ride while it lasts; you may not be the chosen one after all!

Useful Link:

https://www.theguardian.com/science/2015/jun/23/sexism-in-science-did-watson-and-crick-really-steal-rosalind-franklins-data

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